Computer intelligence spots genes linked to Duchenne Muscular Dystrophy

Thursday, March 16, 2017

Using computational intelligence, researchers have identified a set of genes that are "collectively responsible" for Duchenne Muscular Dystrophy (DMD), a genetic disease causing progressive decay in muscles.

Surama Biswas and Sriyankar Acharyya, both from the Department of Computer Science and Engineering, Maulana Abul Kalam Azad University of Technology, West Bengal, mined a dataset of around 50,000 genes to obtain a sub-set containing 30 genes.

"The sub-set containing 30 genes are collectively discriminant in gene expression between DMD affected patients and normal persons. This means that although these genes are present in both affected and normal people, the way the instructions encoded in these genes are used to synthesise gene products (usually proteins), are different in the two categories of people," Biswas told IANS on Thursday.

The genes identified may be clinically investigated to design new drugs and/or modify existing drugs for DMD, Biswas said.

To hunt for the genes in a reasonable amount of time, two algorithms were devised based on existing meta-heuristic algorithms.

Meta-heuristic aims to find good or near-optimal solutions at a reasonable computational cost and time.

DMD affects about one in 5,000 males at birth. It is the most common type of muscular dystrophy. Lack of or defect in muscle cell structural proteins is the basic cause of muscular dystrophy.

Although a gene called DMD has previously been identified, Biswas said the disease is triggered by a collection of all the genes.

Explaining their motivation for the study, Biswas said: "DMD may affect a boy of the age group 3-5 years. DMD initially affects the muscles of limbs causing gradual decay and hampers mobility. Finally it harms the muscles of major organs which leads to death. Application of computational intelligence / soft computing in healthcare of women and kids is the thrust area of our research group."

"Shortage/unavailability of data is always a limitation for computational research. More methods and datasets may always be employed for validating the research," Biswas added.

The study is available in Springer's Computer Society of India (CSI) transactions on ICT (information and communication technology) journal for March issue (volume 5).


Express your comment on this article

Submit your comments...
     
Disclaimer: The views expressed here are strictly personal and IndiansinKuwait.com does not hold any responsibility on them. We shall endeavour to upload/publish as many of the comments that are submitted as possible within a reasonable span of time, but we do not guarantee that all comments that are submitted will be uploaded/published. Messages that harass, abuse or threaten other members; have obscene, unlawful, defamatory, libellous, hateful, or otherwise objectionable content; or have spam, commercial or advertising content or links are liable to be removed by the editors. We also reserve the right to edit the comments that do get published. Please do not post any private information unless you want it to be available publicly.
Image

We chose happiness and compassion; we chose life

It is a widely accepted fact that the ultimate aim of anyone in this world is to attain the state o

Image

Just Imagine

I had the flu. I had never felt so alone. I missed my family. Shivering, I huddled deeper inside th

Image

Open letter to class XII students Some tips on how to live a successful life By Dr. Anis Ahmad

My Dear Students, You are at the threshold of a new beginning. You are going to be an adult. S

Image

Chatting with Chaitali

Chaitali B Roy is the author of ‘Women of Kuwait : Turning Tides’ (Har- Anand Publications) . She i

Image

Good film is a truthful representation of its time, says veteran actor Naseeruddin Shah

The state of Bollywood films is the same where it was started, said Veteran actor Naseeruddin Shah

Image

Childnology

Another year has come and gone, but in the tech world, it means lot more major innovations are on t

Image

Budget 2017: Achche Din- Still Elusive?

This year, the government is changing the British-era legacy by presenting budget on February 1, in

Image

Antiques, Curios and Much More...

Have you ever heard about a museum at home in Kuwait? We, the IIK team were fortunate enough to vis

Image

Safe, Orderly and Regular Migration

"Safe orderly, regular and responsible migration” the notion of migration governance has received a

Image

Happy New Year –Think Different Be Different

Happy new year----This is the phrase we say every year does it change our life? Think different

Image

Experience Indian Corner Tandoori Nights at Al Manshar Rotana Hotel

Al Manshar Rotana Hotel at Fahaheel, Kuwait launched an authentic Tandoori Night with an Indian cor

Image

Biryani & Kebabi restaurant opened at Arabia Mall in Egila

Biryani & Kebabi is the newest addition to Al Sabah & Kohli food and beverage brands. Al Sabah & Ko

Image

Indulge in the luxury of Indian dinner every Tuesday at Jumeirah’s Garden Café

We all love luxury. We have many occasions to celebrate life luxuriously. Be it our anniversary, bi

Image

A delightful treat to our taste buds- Samrat Restaurant Weekend Buffet.

Delicious Food.. Good Company with Family or friends ... That’s what all look for on a weekend. B

Image

Kuwait Cricket announce 25 Probables for ICC World Cricket League Division 5 Qualifier

Kuwait Cricket Board is pleased to announce the 25 Probables for the all important ICC World Cricke

Image

IGC’s 3rd Annual Volley Ball Tournament – 2017

Promoting Unity and Goodwill, Islamic Guidance Center (IGC) Kuwait organized successfully its 3rd

Image

KCWA Cricket Cup 2017

Kuwait Canara Welfare Association (KCWA) held Cricket Cup 2017 on Friday, 3rd March at Boulevard Pa

Image

Aneef & Bastian lifts professional doubles crown in the 6th IBAK- Pizzahut Master’s Cup – 2017

Ilayaraja claims singles title The 6th IBAK – Pizzahut Master’s cup was held on the 23rd and 24

Image

MAK Champions Trophy 2017 – Volley Ball & Throw Ball Tournament

MOGAVEERS ASSOCIATION KUWAIT, the community welfare association of nonresident Mogaveers, based in